AMT Receives a Third of €3.3M EU Grant for Clinical Development of Gene Therapy - Gilde Healthcare

AMT Receives a Third of €3.3M EU Grant for Clinical Development of Gene Therapy

1 februari 2011

Amsterdam Molecular Therapeutics (AMT) will receive €1.1 million (about $1.5 million) of a €3.3 million (approximately $4.5 million) grant being awarded by the European Union 7th Framework Program (FP7) to the AIPGENE consortium, which is working to develop a gene therapy product for treating acute intermittent porphyria (AIP).

As part of the consortium AMT has commercialization rights to the gene therapy product, AMT-021, and projects patient enrolment into a clinical trial could start in 2012.  It says the grant will cover development costs of the product to completion of Phase I/II trials.

AMT-021 is designed to deliver a normal version of the porphobilinogen deaminase (PBDG)  liver protein gene that is mutated in AIP. AMT says its studies have already shown treatment using AMT-021 results in normalization of the PBGD protein in an animal model of AIP as well as prevents the occurrence of attacks and significantly ameliorates the neuropathy that otherwise occurs in untreated animals. The firm in addition notes that work by FIMA (Fundación para la Investigatión Médica Aplicada), which is leading the multinational AIPGENE consortium, has demonstrated that gene expression in the liver will persist for over a year using AAV-mediated delivery methods similar to that used for AMT-021.

Gilde Healthcare company ProVerum Announces Completion of Enrollment for the ProVIDE Clinical Study for BPH and First-use of its New Flexible, Steerable Delivery System

ProVerum Limited, an Irish medical device company developing a minimally invasive solution to treat benign prostatic hyperplasia (BPH) in the doctor's office, today announced completion of enrollment of the ProVIDE pivotal clinical trial to evaluate...
21 maart 2024

Gilde Healthcare sells RAD-x to a consortium of Swiss Life Asset Managers and Vesper Infrastructure Fund I

Gilde Healthcare’s Private Equity Fund (“Gilde Healthcare”), a specialized healthcare investor, has reached a binding agreement to sell its majority stake in RAD-x to a consortium of Swiss Life Asset Managers and Vesper Next Generation...
18 maart 2024

Gilde Healthcare company NIZO acquires lactic acid facility and strengthens partnership with DSM-firmenich

NIZO food research B.V. (“NIZO”) is proud to announce the signature of a long-term contract manufacturing partnership with dsm-firmenich. This strategic alliance encompasses the acquisition of the neighboring lactic acid facility from Vika Nutrition B.V.,...
29 februari 2024