ABLYNX Selects a Novel Pre-Clinical Development Candidate for Administration via Pulmonary Delivery - Gilde Healthcare

ABLYNX Selects a Novel Pre-Clinical Development Candidate for Administration via Pulmonary Delivery

26 March 2010

GHENT, Belgium – Ablynx [Euronext Brussels: ABLX] announced today that it has advanced ALX-0171, a new Nanobody®-based therapeutic programme, into pre-clinical development for the treatment of respiratory synctial virus (RSV) infections. ALX-0171 is a Nanobody product which binds to RSV and neutralizes the virus. The Nanobody will be administered via the lungs and based on the in vivo data it has the potential to be effective both in the prevention of infection as well as in treatment once infection has occurred.

This is Ablynx’s first Nanobody pre-clinical development candidate to be delivered through a route other than injection. Like many Nanobodies, ALX-0171 is very stable with a low propensity to aggregate making it suitable for inhalation. It can also be manufactured at relatively low cost in microbial systems.

“Ablynx’s anti-RSV Nanobody potentially has a clearly differentiated product profile compared with other options currently available for RSV. We expect to conveniently deliver ALX-0171 via the lungs directly to the site of potential disease to provide prophylactic protection, as well as therapeutic treatment which we don’t believe can be offered for this infectious agent by any other marketed drugs today. We also believe ALX-0171 will have a significantly lower cost of goods compared to other biologics currently used in this indication. We are very pleased to illustrate the power of our Nanobody product engine with this announcement of our second pre-clinical candidate nomination in 2010. Earlier this year we nominated ALX-0651, an anti-CXCR4 Nanobody for stem cell mobilization, for preclinical development”

commented Dr. Edwin Moses, Chief Executive Officer and Chairman of Ablynx.

Gilde Healthcare portfolio company Nyxoah announces CE-mark approval to treat complete concentric collapse (CCC) patients

Nyxoah SA (Euronext Brussels/Nasdaq: NYXH) (“Nyxoah” or the “Company”), a medical technology company focused on the development and commercialization of innovative solutions to treat Obstructive Sleep Apnea (OSA), today announced that DEKRA Notified Body has approved...
5 October 2021

Gilde Healthcare portfolio company Noema Pharma appoints Jeffrey Jonas as Independent Chairman of the Board of Directors

Noema Pharma, a Swiss-based clinical stage company targeting orphan central nervous system (CNS) diseases, today announces the appointment of Jeffrey Jonas MD as Chairman of the Board of Directors. Dr. Jonas is a neuropsychiatry expert...
4 October 2021

Gilde Healthcare company Acacia Pharma announces marketing authorization application for BARHEMSYS® in Europe

Acacia Pharma (EURONEXT: ACPH), a commercial stage biopharmaceutical company focused on developing and commercializing novel products to improve the care of patients undergoing serious medical treatments such as surgery, invasive procedures, or cancer chemotherapy, announces...
29 September 2021