ABLYNX Selects a Novel Pre-Clinical Development Candidate for Administration via Pulmonary Delivery - Gilde Healthcare

ABLYNX Selects a Novel Pre-Clinical Development Candidate for Administration via Pulmonary Delivery

March 26, 2010

GHENT, Belgium – Ablynx [Euronext Brussels: ABLX] announced today that it has advanced ALX-0171, a new Nanobody┬«-based therapeutic programme, into pre-clinical development for the treatment of respiratory synctial virus (RSV) infections. ALX-0171 is a Nanobody product which binds to RSV and neutralizes the virus. The Nanobody will be administered via the lungs and based on the in vivo data it has the potential to be effective both in the prevention of infection as well as in treatment once infection has occurred.

This is Ablynx’s first Nanobody pre-clinical development candidate to be delivered through a route other than injection. Like many Nanobodies, ALX-0171 is very stable with a low propensity to aggregate making it suitable for inhalation. It can also be manufactured at relatively low cost in microbial systems.

“Ablynx’s anti-RSV Nanobody potentially has a clearly differentiated product profile compared with other options currently available for RSV. We expect to conveniently deliver ALX-0171 via the lungs directly to the site of potential disease to provide prophylactic protection, as well as therapeutic treatment which we don’t believe can be offered for this infectious agent by any other marketed drugs today. We also believe ALX-0171 will have a significantly lower cost of goods compared to other biologics currently used in this indication. We are very pleased to illustrate the power of our Nanobody product engine with this announcement of our second pre-clinical candidate nomination in 2010. Earlier this year we nominated ALX-0651, an anti-CXCR4 Nanobody for stem cell mobilization, for preclinical development”

commented Dr. Edwin Moses, Chief Executive Officer and Chairman of Ablynx.

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