Symphogen Receives Milestone Payment from Genentech for Antibody - Gilde Healthcare

Symphogen Receives Milestone Payment from Genentech for Antibody

29 november 2010

COPENHAGEN, Denmark and PRINCETON, New Jersey – Symphogen A/S announced today that it has received an undisclosed milestone payment related to an antibody therapeutic in development under its ongoing collaboration with Genentech, Inc., a member of the Roche Group (SIX: RO, ROG; OTCQX: RHHBY). The collaboration covers antibody therapeutics against three infectious disease organisms. 

“The achievement of this milestone demonstrates Symphogen’s ability to rapidly identify antibodies of therapeutic relevance from patients using our unique Symplex discovery platform,”

stated Kirsten Drejer, M.Sc., Ph.D., Chief Executive Officer of Symphogen.

”The increasing severity of infectious diseases has made the pharmaceutical industry aware of the importance of making antibody-based drugs to fight infections. Our results show that the human immune system may be an excellent source for potential new antibody drugs.”

Under terms of their 2008 agreement, Genentech made an undisclosed upfront payment to Symphogen as well as an equity investment in the Company. The total value of the agreement, including research- and development-related milestones and royalty payments, had the potential to exceed $330 million.

About Symplex™

The Symplex™ antibody discovery process begins by isolating B-lymphocytes, which are responsible for making antibodies, from naturally immune human donors displaying a high number of antibodies against a particular target antigen, such as an infectious agent. The Symplex™ technology enables the exact identity of the original donor antibody repertoire to be maintained and mimics the natural human immune response. All processes leading to the isolation of specific antibodies have been automated, making Symplex™ a fast method to generate naturally high-affinity and high-specificity drug leads.

About Sympress™

Symphogen’s Sympress™ technology uses a proprietary mammalian expression platform to enable the manufacturing of target-specific, fully human recombinant polyclonal antibodies. Based on industry-standard antibody expression cell lines, Sympress™ enables consistent and reproducible manufacturing of recombinant polyclonal antibodies.

About Symphogen

Symphogen is developing superior antibody therapeutics (monoclonal, monoclonal mixtures and polyclonal) to help people with serious diseases and significant unmet medical needs. With its proprietary, unique Symplex™ discovery and Sympress™ manufacturing platforms, the company captures the diversity and specificity of the natural immune response in rationally designed recombinant antibody compositions. Symphogen is maturing a diversified pipeline of internal and partnered products across multiple indications including cancer, autoimmune and infectious disease. Symphogen is a private biopharmaceutical company headquartered in Copenhagen, Denmark, with a US subsidiary in Princeton, New Jersey.

Gilde Healthcare company PureSpring announces FDA IND clearance for Phase 1/2 trial for primary IgA nephropathy (IgAN)

Purespring Therapeutics, a precision nephrology company focused on transforming the treatment of kidney diseases, today announces that the U.S. Food and Drug Administration (FDA) has cleared its Investigational New Drug (IND) application for PS-002, enabling...
9 juli 2025

Gilde Healthcare’s private equity fonds bundelt Artinis en NIRx tot wereldleider in neuro-imaging

Gilde Healthcare kondigt vandaag de gecombineerde private equity investering aan in Artinis Medical Systems (Nederland) en NIRx Medical Technologies (Duitsland/Verenigde Staten), beiden pioniers op het gebied van functionele Near-Infrared Spectroscopy (fNIRS). Door deze dubbele transactie...
8 juli 2025

Gilde Healthcare company SpliceBio secures $135 Million financing to advance SB-007 in Stargardt disease and expand pipeline

Financing co-led by new investors EQT Life Sciences and Sanofi Ventures, with participation from Roche Venture Fund, as well as Gilde Healthcare and other existing investors  Proceeds will support clinical development of lead program SB-007...
11 juni 2025