ABLYNX Selects GPCR Targeting Development Candidate and Announces New Data on Alternative Routes - Gilde Healthcare

ABLYNX Selects GPCR Targeting Development Candidate and Announces New Data on Alternative Routes

February 11, 2010

GHENT, Belgium – Ablynx [Euronext Brussels: ABLX] announced today that it has selected a new GPCR targeting development candidate, ALX-0651, an anti-CXCR4 Nanobody which is being developed for hematopoietic stem cell mobilisation. The Company is also releasing new data on pulmonary to systemic administration and needle-free administration of Nanobodies. Ablynx will present an update of its therapeutic pipeline and its recent technology advances at its R&D Investor Update in New York, USA tomorrow at 8.00 a.m. EST.

Selection of GPCR targeting development candidate

In January 2009, Ablynx successfully generated functional Nanobodies against CXCR4, a clinically validated GPCR. Today, the Company has announced that its criteria for preclinical development have been reached and that Ablynx will progress this compound named ALX-0651, towards the clinic. CXCR4 plays an important role in cell movement, tumor growth and metastasis.
 
New data on alternative route of delivery and R&D update

Ablynx has announced additional data on the use of a needle-free device for transdermal delivery and data on the administration of Nanobodies systemically via the pulmonary route.

Specifically, the Company has successfully demonstrated that Nanobodies can be made as a solid formulation in clinically relevant amounts. Furthermore, when administered via a needle-free route, they have shown a similar pharmacokinetic (PK) profile compared with subcutaneously injected Nanobodies.

In addition to previous data showing that Nanobodies can be detected in the systemic circulation following delivery to the lungs, Ablynx has now demonstrated dose-dependent systemic bioavailability and functionality for Nanobodies delivered via the intrapulmonary route. The data indicate that they can survive the lung environment and can then be detected systemically with intact biological activity. Ablynx continues to investigate new routes of administration including oral to systemic, ocular and other forms of transdermal delivery.

“In the last twelve months we have made significant progress in advancing both our therapeutic pipeline and Nanobody-based technology platform,”

commented Dr Edwin Moses, CEO and Chairman of Ablynx.

Gilde Healthcare company SpliceBio secures $135 Million financing to advance SB-007 in Stargardt disease and expand pipeline

Financing co-led by new investors EQT Life Sciences and Sanofi Ventures, with participation from Roche Venture Fund, as well as Gilde Healthcare and other existing investors  Proceeds will support clinical development of lead program SB-007...
June 11, 2025

Gilde Healthcare participates in $75 Million Series D round of SpyGlass Pharma to Advance Its Long-term Drug Delivery Platform for Glaucoma Patients

SpyGlass Pharma, a privately-held ophthalmic biotechnology company, announced the closing of a $75 million Series D financing round. SpyGlass’ Drug Delivery Platform aims to provide multiple years of medical therapy, addressing the need for long-term...
June 3, 2025

Gilde Healthcare company Mainstay Medical Announces Exclusive Coverage of ReActiv8® by Anthem Blue Cross/Blue Shield

Mainstay Medical Holdings plc today announced that Anthem Blue Cross and Blue Shield (“Anthem”) has established favorable coverage for the company’s ReActiv8 Restorative NeurostimulationTM therapy for the treatment of intractable chronic low back pain. ReActiv8...
April 28, 2025